Slit-Robo
نویسندگان
چکیده
منابع مشابه
Slit-Robo signaling.
Slits are secreted proteins that bind to Roundabout (Robo) receptors. Slit-Robo signaling is best known for mediating axon repulsion in the developing nervous system. However, in recent years the functional repertoire of Slits and Robo has expanded tremendously and Slit-Robo signaling has been linked to roles in neurogenesis, angiogenesis and cancer progression among other processes. Likewise, ...
متن کاملStructural insight into Slit-Robo signalling.
Drosophila Slit and its vertebrate orthologues Slit1-Slit3 are secreted glycoproteins that play important roles in the development of the nervous system and other organs. Human Slits are also involved in a number of pathological situations, such as cancer and inflammation. Slits exert their effects by activating receptors of the Robo (Roundabout) family, which resemble cell adhesion molecules i...
متن کاملSlit and Robo Control Cardiac Cell Polarity and Morphogenesis
Basic aspects of heart morphogenesis involving migration, cell polarization, tissue alignment, and lumen formation may be conserved between Drosophila and humans, but little is known about the mechanisms that orchestrate the assembly of the heart tube in either organism. The extracellular-matrix molecule Slit and its Robo-family receptors are conserved regulators of axonal guidance. Here, we re...
متن کاملSlit-miR-218-Robo axis regulates retinal neovascularization
Following the publication of this article, it was brought to our attention that five of the Figures contained in this study were published entirely, or in part, in the following publication, on which several of us were co-authors: Han S, Kong YC, Sun B, Han QH, Chen Y and Wang YC: microRNA-218 inhibits oxygen-induced retinal neovascularization via reducing the expression of roundabout 1. Chin M...
متن کاملSlit/Robo Signaling: Inhibition of Directional Leukocyte Migration
Localized inflammation and the associated influx of leukocytes is a hallmark of the pathogenesis of many diseases. The ability to target the recruitment of leukocytes holds vast therapeutic potential in inflammatory diseases where there is excessive cell recruitment due to an overactive immune response, or the improper resolution of the initial response resulting in chronic leukocyte infiltration.
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ژورنال
عنوان ژورنال: Cancer Cell
سال: 2003
ISSN: 1535-6108
DOI: 10.1016/s1535-6108(03)00166-1